Synthesis, Characterization and Biological Evaluation of Schiff Bases of Propanedihydrazide
نویسندگان
چکیده
A Schiff base series of malonohydrazide was synthesized by reaction of malonohydrazide with various aldehydes. Hydrazine hydrate was reacted with ethyl malonate in ethanol to give malonohydrazide in very good yields. The synthesized compounds were characterized using FTIR and NMR spectroscopies. The biological evaluation of the Schiff bases was carried against Gram +tive and Gram –tive bacterial strains. The investigated bacterial strains were Staphylococcus aureus, Bacillus anthraces, Cyanobacteria bovius and Escherichia coli. Antioxidant evaluation of the synthesized compounds was done by means of DPPH method. The results showed that compound 4 showed good antimicrobial activities.
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